January 22, 2018
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Did you know?

  • We envision a world free from cancer.

    Our research scientists and their teams collaborate with colleagues around the world to conduct cutting-edge research using large data-sets to:
    • understand the causes of cancer
    • find ways to prevent it or detect it early
    • improve outcomes for cancer survivors 
  • Our mission began more than 40 years ago.

    Established in 1974 as the Northern California Cancer Program, the organization later became known as the Northern California Cancer Center. The name was changed again in 2010 when it became the Cancer Prevention Institute of California (CPIC), which reflects the organization's broader scope and demonstrates its large scale impact of preventing cancer before it starts.
  • We are an independent research institute and a valued partner to many.

    Through its collaborative approach, CPIC also serves as an asset to the nation’s leading cancer fighting organizations, including the National Cancer Institute, and to scientists worldwide, educators, patients, and clinicians, and is affiliated with the Stanford Cancer Institute.
  • We work hard to understand who gets cancer and why.

    Our scientists are frequent contributors to major scientific journals, and often present their findings at important cancer-related conferences. CPIC research has been covered by numerous local, national and international media outlets, such as The New York Times and The Washington Post.
  • Every case of cancer counts…and is counted.

    CPIC operates the Greater Bay Area Cancer Registry as part of the National Cancer Institute's Surveillance, Epidemiology and End Results program and the California Cancer Registry. As required by law, the registry gathers data from hospitals and doctors on all cancers diagnosed and treated in nine Bay Area counties. This information is used to produce cancer statistics and as a platform for research to understand cancer occurrences and survival. Our registry regularly earns Gold Standard Certification by the North American Association of Central Cancer Registries.
  • Our educational efforts reach people of all ethnicities and backgrounds.

    Our Community Education team provides important information to cancer survivors, health professionals and others through conferences and publications on many cancer-related topics including employment, patient advocacy, care giving, specific cancers, and treatments.

  • Breast cancer rates decline when hormone therapy is stopped.

    CPIC was first to report on the alarmingly high and increasing rates of breast cancer in the Bay Area and Marin County in the 1990s. In subsequent studies, CPIC found that when women stopped taking hormone replacement therapy, breast cancer rates declined immediately and dramatically. This showed that hormone therapy was a major contributor to the high rates previously reported and identified one clear path to breast cancer prevention.
  • Our work to associate tanning beds and melanoma prompted legislation.

    CPIC described increased occurrence of melanoma in young women in California, particularly in high socioeconomic areas, implicating use of tanning beds as one cause. This finding led to passage of the first statewide legislation to ban minors from using tanning beds, which should ultimately reduce occurrences of deadly melanoma in young persons.
  • Physical activity lowers your risk of Breast Cancer

    CPIC found that risk of breast cancer was lower for women engaging in more physical activity, such as walking and biking, doing household chores and yard work, and being active on the job. This shows a simple and practical way women can help prevent breast cancer from occurring.
  • Second-hand smoke increases the risk of lung and breast cancer.

    CPIC studies have shown that women exposed to second-hand tobacco smoke have a higher risk of lung cancer even if they don't smoke, and that exposure to household smoke increases their risk of breast cancer over and above the risk they incur from smoking themselves. These findings have been important in leading to anti-smoking legislation.
  • Vitamin D may reduce the risk of prostate cancer.

    CPIC assessed whether sun exposure, which is the main source of vitamin D, is related to prostate cancer risk. Using the difference in skin color measured on the forehead and upper underarm as an indicator of sun exposure, the study found that prostate cancer risk was reduced by 50% in men with a high sun exposure index, with an even higher reduction in risk noted in men with certain alterations in the vitamin D receptor gene.
  • Survival outcomes differ among Asian women of different ethnic backgrounds.

    CPIC was the first to show that breast cancer survival is not uniform across women of different Asian ethnicities, irrespective of how advanced the cancer was when diagnosed. In California, Korean, South Asian and Vietnamese women had the poorest survival after breast cancer, pointing to the need in these communities for better screening and/or breast cancer treatment.
  • Melanoma is on the rise throughout California.

    CPIC demonstrated that the rates of both early and more advanced melanomas were rising in all populations in California. This disturbing finding signals a true and alarming epidemic of this deadly cancer, and it has been cited over 245 times in the medical literature since 2009 because it identifies a major public health problem.
  • Survival disparities occur across many cancer types.

    CPIC showed that survival after follicular lymphoma, a common form of this cancer, is lower in poorer communities than in more affluent communities. This demonstrates population disparities in cancer treatment and shows a need in poorer communities for more access to skilled lymphoma care, including access to new successful drug treatments.
  • Our nail salon studies have widespread positive impact.

    CPIC found that California nail salons had higher than expected levels of carcinogens and other banned substances in the air, identifying the need for better standards and the importance of clarifying whether such exposures lead to cancer and other undesirable health outcomes.
  • Tailored approaches to healthcare are needed to address cultural differences.

    CPIC used two approaches to learn how best to help Vietnamese communities in California receive lifesaving colorectal cancer screening: one approach involved lay health workers directly educating the community on the importance of screening, and the other involved advertising about colorectal cancer screening. CPIC found that the use of lay health workers worked best to improve the screening rate, proving that organized community involvement improves colorectal screening practices among Vietnamese-Americans in California.
  • Lung cancer afflicts nonsmoking women more than men.

    CPIC was the first to show definitively that among nonsmokers, women were more likely than men to have lung cancer. Until this paper, there were no hard data about the incidence of lung cancer in nonsmokers. This study has been cited extensively as motivation for other research to understand the reasons why.
  • Genetic screening is especially important for African American and Hispanic women.

    CPIC was the first to study the level of BRCA1 mutations (genetic changes responsible for increased risk of breast cancer) in nonwhite women. This work found that young African American and Hispanic women with breast cancer had a particularly high prevalence of BRCA1 mutations, and signaled the importance to these communities and their doctors of screening for this mutation when indicated.

Press Releases

Breastfeeding Found to Reduce the Risk of Triple Negative Breast Cancer in Women Under Age 50

FREMONT, CA (January 22, 2018) — Triple negative breast cancer (TNBC) is an aggressive subtype with few known risk factors. In a study led by the Cancer Prevention Institute of California and epublished ahead of print on January 13 in the International Journal of Cancer, researchers found that women under the age of 50 who breastfed for at least 24 months over their lifetime had a lower risk of developing TNBC. For women with three or more full-term pregnancies, risk increased two-fold if they did not breastfeed or only did so for less than a year. No increase in risk was seen for women who breast-fed for more than a year.  

These findings suggest that breastfeeding may mitigate the elevated TNBC risk associated with pregnancies in younger women. None of these associations were observed among women age 50 or older. 

TNBC breast cancer lacks expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor. This type of breast cancer has the worst prognosis and lacks targeted treatment. TNBC is more common among African Americans, Hispanics and younger women. About 12% of all invasive breast cancers are diagnosed as TNBC.
  
According to Esther M. John Ph.D., M.S.P.H., the lead researcher of the study, “Our finding that breastfeeding lowers the risk of TNBC in younger women is important, particularly for
those who have several children. Almost 40% of breast cancers diagnosed in younger African American women are TNBC. The benefits of breastfeeding regarding breast cancer, and TNBC in particular, is an important public health message for young women starting a family.”   

Breast Cancer Family Registry, and the Los Angeles County Asian American Breast Cancer Study, which collectively included a total of 5,669 women, 558 with TNBC and 5,111 controls who never had breast cancer. This is one of the largest studies of TNBC. Only a few studies have examined the link between childbirth and breastfeeding and the risk of developing TNBC. 
 
To conduct this study researchers combined data from three population-based breast cancer studies; the San Francisco Bay Area Breast Cancer Study, the Northern California site of the The Breast Cancer Etiology in Minorities Study was funded by grant R03 CA199343 from the National Cancer Institute. The San Francisco Bay Area Breast Cancer Study was supported by grants R01 CA63446 and R01 CA77305 from the National Cancer Institute, grant DAMD17-96-1-6071 from the U.S. Department of Defense and grant 7PB-0068 from the California Breast Cancer Research Program. The Northern California site of the Breast Cancer Family Registry was funded by grant UM1 CA164920 from the National Cancer Institute. 

About the Cancer Prevention Institute of California
The Cancer Prevention Institute of California is a nonprofit organization dedicated to preventing cancer and to reducing its burden where it cannot yet be prevented. We are the only freestanding research institution working solely to prevent cancer using extensive population data. Our researchers study a wide range of cancer risk factors, such as racial/ethnic background, socioeconomic status, age, occupation, gender, genetic predisposition, geographic location, environment and lifestyle to determine how these factors affect frequency, distribution and types of cancers. For more information, visit the CPIC website at www.cpic.org

Media Contact: 
Donna Lock, 510-608-5160 | donna.lock@cpic.org

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