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  • We envision a world free from cancer.

    Our research scientists and their teams collaborate with colleagues around the world to conduct cutting-edge research using large data-sets to:
    • understand the causes of cancer
    • find ways to prevent it or detect it early
    • improve outcomes for cancer survivors 
  • Our mission began more than 40 years ago.

    Established in 1974 as the Northern California Cancer Program, the organization later became known as the Northern California Cancer Center. The name was changed again in 2010 when it became the Cancer Prevention Institute of California (CPIC), which reflects the organization's broader scope and demonstrates its large scale impact of preventing cancer before it starts.
  • We are an independent research institute and a valued partner to many.

    Through its collaborative approach, CPIC also serves as an asset to the nation’s leading cancer fighting organizations, including the National Cancer Institute, and to scientists worldwide, educators, patients, and clinicians, and is affiliated with the Stanford Cancer Institute.
  • We work hard to understand who gets cancer and why.

    Our scientists are frequent contributors to major scientific journals, and often present their findings at important cancer-related conferences. CPIC research has been covered by numerous local, national and international media outlets, such as The New York Times and The Washington Post.
  • Every case of cancer counts…and is counted.

    CPIC operates the Greater Bay Area Cancer Registry as part of the National Cancer Institute's Surveillance, Epidemiology and End Results program and the California Cancer Registry. As required by law, the registry gathers data from hospitals and doctors on all cancers diagnosed and treated in nine Bay Area counties. This information is used to produce cancer statistics and as a platform for research to understand cancer occurrences and survival. Our registry regularly earns Gold Standard Certification by the North American Association of Central Cancer Registries.
  • Our educational efforts reach people of all ethnicities and backgrounds.

    Our Community Education team provides important information to cancer survivors, health professionals and others through conferences and publications on many cancer-related topics including employment, patient advocacy, care giving, specific cancers, and treatments.

  • Breast cancer rates decline when hormone therapy is stopped.

    CPIC was first to report on the alarmingly high and increasing rates of breast cancer in the Bay Area and Marin County in the 1990s. In subsequent studies, CPIC found that when women stopped taking hormone replacement therapy, breast cancer rates declined immediately and dramatically. This showed that hormone therapy was a major contributor to the high rates previously reported and identified one clear path to breast cancer prevention.
  • Our work to associate tanning beds and melanoma prompted legislation.

    CPIC described increased occurrence of melanoma in young women in California, particularly in high socioeconomic areas, implicating use of tanning beds as one cause. This finding led to passage of the first statewide legislation to ban minors from using tanning beds, which should ultimately reduce occurrences of deadly melanoma in young persons.
  • Physical activity lowers your risk of Breast Cancer

    CPIC found that risk of breast cancer was lower for women engaging in more physical activity, such as walking and biking, doing household chores and yard work, and being active on the job. This shows a simple and practical way women can help prevent breast cancer from occurring.
  • Second-hand smoke increases the risk of lung and breast cancer.

    CPIC studies have shown that women exposed to second-hand tobacco smoke have a higher risk of lung cancer even if they don't smoke, and that exposure to household smoke increases their risk of breast cancer over and above the risk they incur from smoking themselves. These findings have been important in leading to anti-smoking legislation.
  • Vitamin D may reduce the risk of prostate cancer.

    CPIC assessed whether sun exposure, which is the main source of vitamin D, is related to prostate cancer risk. Using the difference in skin color measured on the forehead and upper underarm as an indicator of sun exposure, the study found that prostate cancer risk was reduced by 50% in men with a high sun exposure index, with an even higher reduction in risk noted in men with certain alterations in the vitamin D receptor gene.
  • Survival outcomes differ among Asian women of different ethnic backgrounds.

    CPIC was the first to show that breast cancer survival is not uniform across women of different Asian ethnicities, irrespective of how advanced the cancer was when diagnosed. In California, Korean, South Asian and Vietnamese women had the poorest survival after breast cancer, pointing to the need in these communities for better screening and/or breast cancer treatment.
  • Melanoma is on the rise throughout California.

    CPIC demonstrated that the rates of both early and more advanced melanomas were rising in all populations in California. This disturbing finding signals a true and alarming epidemic of this deadly cancer, and it has been cited over 245 times in the medical literature since 2009 because it identifies a major public health problem.
  • Survival disparities occur across many cancer types.

    CPIC showed that survival after follicular lymphoma, a common form of this cancer, is lower in poorer communities than in more affluent communities. This demonstrates population disparities in cancer treatment and shows a need in poorer communities for more access to skilled lymphoma care, including access to new successful drug treatments.
  • Our nail salon studies have widespread positive impact.

    CPIC found that California nail salons had higher than expected levels of carcinogens and other banned substances in the air, identifying the need for better standards and the importance of clarifying whether such exposures lead to cancer and other undesirable health outcomes.
  • Tailored approaches to healthcare are needed to address cultural differences.

    CPIC used two approaches to learn how best to help Vietnamese communities in California receive lifesaving colorectal cancer screening: one approach involved lay health workers directly educating the community on the importance of screening, and the other involved advertising about colorectal cancer screening. CPIC found that the use of lay health workers worked best to improve the screening rate, proving that organized community involvement improves colorectal screening practices among Vietnamese-Americans in California.
  • Lung cancer afflicts nonsmoking women more than men.

    CPIC was the first to show definitively that among nonsmokers, women were more likely than men to have lung cancer. Until this paper, there were no hard data about the incidence of lung cancer in nonsmokers. This study has been cited extensively as motivation for other research to understand the reasons why.
  • Genetic screening is especially important for African American and Hispanic women.

    CPIC was the first to study the level of BRCA1 mutations (genetic changes responsible for increased risk of breast cancer) in nonwhite women. This work found that young African American and Hispanic women with breast cancer had a particularly high prevalence of BRCA1 mutations, and signaled the importance to these communities and their doctors of screening for this mutation when indicated.

For Study Participants

Here are answers to common questions for individuals participating in research studies at the Cancer Prevention Institute of California (CPIC).


Why does CPIC conduct research?

Our researchers conduct studies because we want to know why cancer happens and how we can improve the survival and quality of life for people living with cancer.

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How does CPIC conduct research?

Answering these questions means working with a lot of people. We need to talk with individuals who have cancer as well as those who do not. People without cancer are recruited so that we can compare their experiences with those of people who do have cancer. This gives us a greater understanding of which characteristics may be more common in people who develop cancers. In our interview studies, we may ask questions about lifestyle issues such as exercise and nutrition or about factors related to the environment, cancer treatment, and family illness history. Sometimes we need to obtain biological samples such as blood and mouth cells so that we can study cancer causes and outcomes at a genetic and molecular level. In other studies, we may need to know how people make decisions about a diagnosis of cancer, such as where they get their information and how they talk with their doctor about cancer.

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What type of research does CPIC do?

Our research studies provide important information about what causes cancer, how to prevent it, and how to help those who have it. We study many different cancers, including breast, prostate, lymphoma, ovarian, colorectal, lung and thyroid, as well as a broad range of exposures, including diet, physical activity, genetic/molecular factors and viruses.

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How does CPIC find people to participate in its research?

We find the names of individuals whom we contact through several resources. People diagnosed with cancer are identified through the California Cancer Registry (CCR). Because cancer is a "reportable disease" in California, state law requires that doctors, hospitals and other facilities that diagnose and treat cancer patients report to the CCR each new cancer diagnosis and some information about the cancer patient. The California Department of Health Services runs the CCR. The California legislature set up the CCR because it is needed to support research to monitor cancer and to better understand the disease in our state. The CCR is operated as 10 regional registries collecting information about patients in each region. CPIC operates the two regional registries covering the Greater Bay Area, including the counties of San Francisco, Marin, Contra Costa, San Mateo, Alameda, Santa Clara, Santa Cruz, Monterey and San Benito.

CPIC uses the data collected by the cancer registries to produce statistics describing cancer occurrence - that is, cancer incidence and mortality - in different segments of the population. These grouped data do not contain any information about individuals. Under state law, data that are not grouped, which we also call confidential cancer information, can be used only for cancer research purposes. Confidential cancer information is available only to qualified researchers from nonprofit or educational institutions and only if certain other conditions are met. Thus, before the information is given to a researcher, the proposed study must first be reviewed by one of several specific scientific committees to show that the project will help us understand how cancer is caused or avoided. In addition, the study must be approved by a federally approved Institutional Review Board, which monitors and protects the rights of research subjects.

The Health Insurance Portability and Accountability Act (HIPAA) does not change the required reporting of data to the cancer registries. Because CPIC, as part of the California Cancer Registry, is lawfully considered to be important to public health, health care providers do not need patient authorization to report to the registry.

For more information about cancer reporting in California, you can request a copy of California's Cancer Reporting System and Monitoring Cancer in California by calling (916) 779-0300; by visiting the California Cancer Registry website at www.ccrcal.org or by writing to the following address:

The California Cancer Registry
Department of Health Services
Cancer Surveillance Section
1700 Tribute Road, Suite 100
Sacramento, CA 95815-4402

There are additional resources that we use for finding individuals to participate in our research. When we need to recruit people without cancer to compare with individuals who have been diagnosed with cancer, we may use a variety of methods to identify eligible people, such as calling randomly generated telephone numbers. Information obtained from study participants without cancer is handled under the same strict privacy guidelines that apply to information obtained from participants with cancer, as described above. The new "Do Not Call" legislation, which applies to telemarketers, does NOT apply to public health research such as that conducted by CPIC.

Individuals always have the right to refuse to participate in a study.
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How does CPIC protect my rights as a study participant?

All of our research follows federal and state laws requiring the protection of people who participate in research studies. Every health research study that involves contact with people or uses people's private information must receive approval from a federally registered Institutional Review Board. At CPIC, the Institutional Review Board (IRB) is composed of CPIC and external scientific members, cancer survivors, medical arts practitioners, and community members. The group has expertise in bioethics, data security, epidemiology, and public health, and some have participated in research studies themselves. The IRB reviews all research studies to make sure that people who consider participating in a study are fully informed about the research, have the freedom to participate or not to participate, and are protected from too much risk when taking part in the study. The IRB is specifically charged to ensure the following:
  • Risks to participants are minimized.
  • Risks to participants are reasonable in relation to anticipated benefits, if any, and the importance of the knowledge that may reasonably be expected to result.
  • Selection of participants is equitable.
  • Informed consent is sought from each prospective participant or the participant's legally authorized representative.
  • Informed consent is appropriately documented.
  • When appropriate, the research plan makes adequate provision for monitoring the data collected to ensure the safety of participants.
  • When appropriate, there are adequate provisions to protect the privacy of participants and to maintain the confidentiality of data.
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How does CPIC manage financial conflicts of interest?

The CPIC policy on conflicts of interests affecting research grants and contracts is available at the following link: Conflict of Interest Policy-Grants and Contracts

Current disclosures include the following: 

None at present time.

For more information or inquiries about a particular research study, please contact Matt O'Grady via email or at (510) 608-5003.
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How does CPIC protect my personal information?

We carefully guard private information obtained from study participants. All researchers and their staff who receive funding from the federal or state government are required to complete training and receive certification from the National Institutes of Health (NIH) on the ethical conduct of research involving human subjects. In addition, all CPIC staff members are required to complete training in working with private, or confidential, information on an annual basis.

To ensure that confidentiality is maintained, all documents are stored in secure, locked areas, and databases are secured behind the organizational firewall. Names, contact information, and other identifying information are kept separate from information obtained during an interview with links minimized and available to only key personnel. CPIC never reports or published results that identify specific people. Instead, we compile data from groups of people and report the statistical summaries. These procedures are well established at CPIC and have been used extensively and successfully over the last 30 years.

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