Circadian Genes and Breast Cancer in African Americans and Caucasians

Principal Investigator:
Peggy Reynolds, Ph.D.
Co-Investigator:
Ann W. Hsing (Stanford University), Ph.D., Christopher Haiman, Sc.D. (University of Southern California), Peter Kraft, Ph.D., and Sara Lindstrom, Ph.D. (Harvard University), Kai Yu, Ph.D. (National Cancer Institute)
Collaborators:
Funding Source:
National Cancer Institute
Funding Period:
Study Website:

Disruptions of the circadian rhythm--the biological “clock” that regulates our body on a 24-hour cycle--have been classified by the International Agency for Research on Cancer recently as a probable carcinogen to humans, based in part on findings from studies of breast cancer. How the body responds to disruption of circadian rhythms is due in part to differences in a set of circadian genes that control the body’s circadian rhythm. This project studies whether differences in circadian genes may be related to breast cancer risk. It also addresses whether differences in circadian genes between African American and Caucasian women contribute to the disparity in hormone-negative breast cancers seen between these two racial groups. This project will make use of already collected genetic data on circadian genes from two large studies of breast cancer in African American and Caucasian American women (the Breast and Prostate Cancer Cohort Consortium and the African American Breast Cancer Consortium; 5,400 female breast cancer cases and 5000 healthy female controls).

Publications:

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