Dietary and Environmental Exposure to Cadmium and the Risk of Endometrial Cancer

Principal Investigator:
Peggy Reynolds, Ph.D., David O. Nelson, Ph.D.
Rudy Rull, Ph.D. (Principal Investigator) (University of Nevada, Reno)
Funding Source:
National Institute of Environmental Health Sciences
Funding Period:
Study Website:

Cadmium is a heavy metal released into the environment by industry, mining and combustion. It is found in cigarette smoke, certain foods, and is classified as a human carcinogen.  It has shown strong estrogen-like activity in animals, but there has been little research to confirm hormonal effects in humans.  This study is one of the first to explore how cadmium exposure may influence risk of endometrial cancer in 300 women with endometrial cancer and 600 women without it, using measures of cadmium (in urine) together with information on cadmium exposure from dietary and environmental sources.  This study will provide the first estimates of the effects of dietary, environmental, and total cadmium exposure on endometrial cancer.


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