Disparities in Breast Cancer Development and Survival in Hispanic and non-Hispanic White Women

Principal Investigator:
Esther M. John, Ph.D. (Principal Investigator)
Martha Slattery, Ph.D. (Principal Investigator) (University of Utah), Roger Wolff, Ph.D. (University of Utah), Gabriela Torres-Mejia, Ph.D., (Instituto Nacional de Salud Pública), Kathy Baumgartner, Ph.D., (University of Louisville), Lisa Hines, Sc.D., (University of Colorado), Anna Giuliano, Ph.D. (Moffitt Cancer Center)
Funding Source:
National Cancer Institute
Funding Period:
Study Website:

The Breast Cancer Health Disparities Study combined DNA and interview data from three studies conducted in the U.S. and Mexico, including CPIC’s San Francisco Bay Area Breast Cancer Study led by Dr. John. The combined study is the largest to date in women of Hispanic background, comprising over 4,700 U.S. Hispanic and Mexican women who are being compared to over 3,000 U.S. non-Hispanic white women. The study is investigating the role of genetic and lifestyle factors that contribute to the well established differences in breast cancer incidence and survival after diagnosis between the two populations. On-going work is focused on differences in genes involved in the control of hormones, inflammation and energy factors. Given the wide range of genetic ancestry among the U.S. Hispanic and Mexican women (with more or less Indigenous American ancestry), a unique focus of this study is to evaluate whether the relationships between genetic and lifestyle factors and breast and risk and survival differ by genetic ancestry.


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