Leveraging the profound differences in risk seen among U.S. Latinas, this project will use a broad exploratory approach, “exposomics”, to understand how the migration experience, with its concomitant changes in environmental and lifestyle-related exposures, affects the risk of breast cancer in this population. Specificallly, we will evaluate multiple molecules that are detectable within the body of individuals. Similar to the shift from candidate gene studies to genome-wide association studies (GWAS) in investigations of the genetic etiology of diseases, our project proposes a shift from the study of known exposures, to an exposure-wide analysis. In addition, we will spatially contextualize the observed levels of internal chemicals in order to gain new insights regarding possible sources of exposures. This project will leverage survey data collected from the San Francisco Bay Area Breast Cancer Study (PI: E. John), and neighborhood contextual data from the California Neighborhoods Data System (PI: S. Gomez).
Scarlett Lin Gomez, Ph.D., Esther John, Ph.D.
Laura Fejerman, Ph.D., Martyn Smith, Ph.D.
National Cancer Institute