Getting a Jump on Breast Cancer with a Tool to Classify Genomic Risk

Principal Investigator:
Ingrid Oakley-Girvan, Ph.D. and Scarlett Lin Gomez, Ph.D.
Robert West, M.D., Ph.D., and Allison Kurian, M.D. (Stanford University); Megan Troxell, M.D., Ph.D. (Oregon Health Sciences University)
Funding Source:
California Breast Cancer Research Program
Funding Period:
Study Website:
This project aims to develop molecular-based algorithms of breast cancer risk to help identify tumors that have a high likelihood of progressing to invasive carcinoma.  It will do this by identifying genetic alterations in two types of breast biopsies:  pre-invasive neoplasia found adjacent to cancer and pre-invasive neoplasia without adjacent cancer.  Improved knowledge of molecular markers of risk from these biopsies will help reduce cancer incidence and mortality by indicating when and where aggressive clinical treatments (surgery, chemoprophylaxis) and/or close follow-up with the possible intensive surveillance techniques (breast MRI) will most benefit patients.

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