The LEGACY (Lessons in Epidemiology and Genetics of Adult Cancer from Youth) Girls Study is a follow-up study of young girls, half of whom are at increased breast cancer risk due to their family history. The study will examine how lifestyle, environment, and biology affect their growth and development, and how a family history of breast cancer affects psychosocial adjustment and behaviors throughout childhood and adolescence. A total of 1,040 girls aged 6-13 years have been recruited from six centers in the US and Canada, including 362 girls from the San Francisco Bay Area, and they are being contacted every six months for additional data and biospecimen collection. The LEGACY Girls Study is one of the first to delineate the importance of childhood and adolescent exposures as to their effects on breast development and other markers of breast cancer risk.
Esther M. John, Ph.D. (Principal Investigator)
Mary Beth Terry, Ph.D. (Columbia University), Irene Andrulis, Ph.D. (Mount Sinai Hospital, New York), Saundra Buys, M.D. (Huntsman Cancer Center), Mary Daly, M.D., Ph.D. (Fox Chase Cancer Center), Angela Bradbury, M.D. (University of Pennsylvania)
National Cancer Institute