Lung Cancer in Never Smokers: Incidence, Risk Factors, and Molecular Characteristics in Asian American, Native Hawaiian and Pacific Islander Females

Principal Investigator:
Scarlett Lin Gomez, Ph.D. & Iona Cheng Ph.D., (multiple PIs), Mindy DeRouen, Ph.D., Salma Shariff-Marco, Ph.D., Peggy Reynolds, Ph.D., David Nelson, Ph.D.
Caroline Thompson, Ph.D., Harold Luft, Ph.D., Beth Waitzfelder, Ph.D., Heather Wakelee, M.D., Robert Haile, Ph.D., Manali Patel, M.D.
Funding Source:
National Cancer Institute
Funding Period:
Study Website:
For females of Asian Americans, Native Hawaiians and Pacific Islanders (AANHPI) ethnic groups, lung cancer is the 3rd or 4th most common cancer, but the most common cause of cancer death. The burden of lung cancer among AANHPI females is striking considering their low prevalence of smoking, that more than half of lung cancers occur in never smokers, and contributing risk factors beyond smoking remain largely unknown. To address these gaps, the objective of our study is to utilized prospective data from two large electronic health record (EHR) databases, comprising 3.2 million individuals, 1.8 million females, and over 240,000 AANHPI females, with up to 15 years follow-up, to estimate their lung cancer incidence and characterize the epidemiology of lung cancer by specific single and mixed race/ethnicity and smoking status. This study will use EHR data from the Northern California Sutter Health system and from Kaiser Permanente Hawaii – each specifically selected for their robust AANHPI representation and high quality data. Coupled with a focus on distinct subpopulations defined by race/ethnicity (including well-defined mixed race/ethnic groups), smoking status, environmental characteristics, and tumor-based molecular markers, this highly efficient study will provide much-needed information on lung cancer risk among AANHPI never smokers, serving as a critical evidence base to inform screening, research, and public health priorities in this growing population.

© Cancer Prevention Institute of California