Menopausal Transition – a Window of Susceptibility for the Promotion of Breast Cancer from Environmental Exposures

Principal Investigator:
Peggy Reynolds, Ph.D., David Nelson, Ph.D.
Shiuan Chen, Ph.D., Susan L. Neuhausen, Ph.D., Leslie Bernstein, Ph.D., R.N., Kimlin Tam Ashing, Ph.D., Noriko Kanaya, Ph.D., Yuan Chun Ding, Ph.D., M.S., Xiwei Wu, M.D., Ph.D., Sierra M. Li, Ph.D., and Tim Synold, Pharm.D.
Funding Source:
National Institute for Environmental Health Sciences / City of Hope
Funding Period:

This study explores the menopausal transition as a window of susceptibility for environmental exposures exposure. The menopausal transition begins when ovarian function begins to decline and ends at menopause when ovarian function ceases, which results in low levels of estrogens. Using biospecimens collected from CTS participants, this study is evaluating the role of environmental disrupting chemicals (EDCs)—individually and combined—in the development of breast cancer during menopausal transition.


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