PAHs and puberty in girls at increased breast cancer risk

Principal Investigator:
Esther M. John, Ph.D.
Regina Santella, Ph.D. (Columbia University); Mary Beth Terry, Ph.D. (Columbia University)
Funding Source:
California Breast Cancer Research Program
Funding Period:

This project, based on the California site of the LEGACY Girls Study, will examine a possible link between exposure to environmental chemicals and pubertal development. We will measure polycyclic aromatic hydrocarbons (PAH) in urine and blood samples and examine the association of PAH exposures with several indices of pubertal development (age at onset of breast development, age at menarche, pubertal tempo) and with breast tissue composition measured by optical spectroscopy. We will also assess whether the impact of PAH exposures on puberty differs between girls with a family history of breast cancer and those without a family history.


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