Pregnancy-induced hypertension, IGF1R, and breast cancer risk

Principal Investigator:
Peggy Reynolds, Ph.D.
Mark Powell, M.D. (Zero Breast Cancer)
Funding Source:
Avon Foundation for Women / National Cancer Institute.
Funding Period:
Study Website:

Hypertension in pregnancy has been associated with decreased future risk of breast cancer in many but not all studies. In the Marin Women’s Study, pregnancy-induced hypertension was shown to interact with the T allele of a functional IGF1R gene variant, rs2016347, to result in lower breast density, as well as decreased breast cancer risk. Our objective was to explore these findings in a larger sample of women from the California Teachers Study (CTS).


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