Radiation Exposure, Genes, and Bilateral Breast Cancer

Principal Investigator:
Esther M. John, Ph.D.
Jonine Bernstein, Ph.D. (Principal Investigator) (Memorial Sloan-Kettering Cancer Center ), Kathleen Malone, Ph.D. (Fred Hutchinson Cancer Research Center), Charles Lynch, Ph.D. (University of Iowa), Leslie Bernstein, Ph.D. (City of Hope National Medical Center), Marilyn Stowall, Ph.D. (University of Texas M.D. Anderson Cancer Center), Robert Haile, Dr.P.H. (Stanford University), Julia Knight, Ph.D. (Mount Sinai Hospital, New York), Lene Mellemkjær, Ph.D. (Danish Cancer Society)
Funding Source:
National Cancer Institute
Funding Period:
Study Website:
The Women’s Environment Cancer and Radiation Epidemiology (WECARE) Study is an international  study of the epidemiology of contralateral breast cancer (that is, breast cancer occurring in the second breast of women with a previous breast cancer).  With information from the WECARE Study, researchers investigate the role of various factors in the development of contralateral breast cancer, including interaction between treatment-related radiation exposure and genetic susceptibility, reproductive and lifestyle factors, and mammographic density. The San Francisco Bay Area component of this study, led by Dr. John, has enrolled 695 women.

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